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KMID : 0854720080280040305
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Korean Journal of Asthma, Allergy and Clinical Immunology
2008 Volume.28 No. 4 p.305 ~ p.308
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A Case of Wells’ Syndrome Presented High Fever without Peripheral Eosinophilia
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Hwang Ji-Won
Kim Hye-Young
Oh Se-Hoon
Lee Chang-Hoon
Jeung Yun-Jin
Lee Byung-Jae
Choi Dong-Chull
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Abstract
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Wells’ syndrome is eosinophilic cellulitis characterized clinically by an acute dermatitis resembling cellulitis. Peripheral eosinophilia is not necessary for the diagnosis but is present in approximately 50% of during active disease. We report a case of Wells’ syndrome which was clinically difficult to diagnose without biopsy. A 26-year-old woman presented with high fever and skin lesion mimicking urticaria migrating in chest, abdomen and extremities. The skin lesion was aggravated with rise in temperature and was evanescent. Well-demarcated swollen and tender erythematous plaques were in ear lobes, neck, chest, abdomen and extremities. Viral markers, blood cultures and other laboratory test results related to infections such as EBV, CMV and Limedisease were negative. FANA, ANCA and ENA were also negative. There was no peripheral eosinophilia. Skin biopsy performed from the volar side of right forearm revealed the infiltration of eosinophils with multifocal collagen degeneration in dermis without vasculitic process, consistent with the early stage of Wells’ syndrome. The patient was treated with intravenous methylprednisolone and antihistamine with remarkable clinical improvement. Wells’ syndrome should be included in the differential diagnosis of any skin lesion mimicking cellulitis even without peripheral eosinophilia. Confirmatory skin biopsy is mandatory for the definite diagnosis of this disease.
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KEYWORD
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Cellulitis, Eosinophilia
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